The COVID-19 pandemic represents a global crisis with high demands for the general population. In this research, we conducted a cross-sectional online study (N = 2278), which was diverse regarding age, employment, and family status to examine emotional well-being in times of the lockdown. We focused on inter-role conflict as a central factor associated with well-being. We tested whether individuals with high inter-role conflict (e.g. care-taker and employee) would appraise the lockdown more negatively than those experiencing low role-conflict and whether this would be associated with fatigue. In addition, we looked at gender as moderating this link. Latent modelling only showed small gender specific effects in the non-parent sample. However, in the parent sample, we found that although men experience less inter-role conflict than women on average, they coped significantly less well with it. We discuss the role of gender stereotypes in creating these psychological obstacles for men and women.